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Indian Journal of Veterinary Pathology
Year : 2007, Volume : 31, Issue : 1
First page : ( 36) Last page : ( 39)
Print ISSN : 0250-4758.

Distribution of histologically detectable iron complexes in small intestine and mesenteric lymph node lesions of paratuberculosis in sheep and goats

Kurade N.P.1, Rajukumar K.2, Tripathi B.N.

1Division of Pathology, IVRI, Regional Station, Palampur (HP)

2High Security Animal Disease Laboratory, Bhopal (MP), Indian Veterinary Research Institute, Izatnagar-243 122 (UP), India

†Corresponding author, E-mail: bntripathi1@yahoo.co.in

Abstract

Iron is essential for the intra-cellular survival and multiplication of Mycobacterium avium subsp. paratuberculosis (MAP) in macrophages. Presence of histologically detectable iron complexes in the small intestine and mesenteric lymph nodes of experimentally MAP infected sheep (n=22) and naturally infected goats (n=21) was correlated with the type of lesion and the mycobacterial load. Sheep and goats with grade 3 or 4 lesions with abundant acid-fast bacilli had more siderotic macrophages compared to those with grade 1 or 2 lesions with lesser mycobacterial load. Iron was not demonstrable in most of the uninfected intestine and lymph node sections. Existence of a close relationship between the presence of iron complexes in MAP infected tissues and severity of lesions as well as the mycobacterial load indicated the importance of iron levels in the tissue microenvironment in MAP multiplication.

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Key words

Goat, iron complexes, paratuberculosis, sheep.

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