Biological Activity of Some (2E)-Substituted-2-Ethylidene-5,6-Diphenylimidazo[2,1-b][1,3]Thiazol-3-(2H)-Ones Bhaskar VH1,*, Kumar M2, Balakrishnan BR2, Sangameswaran B2 1M.P. Patel College of Pharmacy, Kapadwanji, Gujarat- 387 6202 2Medicinal Plant Research Centre, Vinayaka Mission's College of Pharmacy, Vinayaka Missions University, Salem-636 008, Tamil Nadu, India *Corresponding Author E-mail: vhbhaskar@yahoo.co.in
Online published on 13 March, 2013. Abstract Certain (2E)-substituted-2-ethylidene-5,6-diphenylimidazo[2,1-b][1,3]thiazol-3-(2H)-ones (4a-f) have been synthesized by the condensation of 4,5-diphenylimidazoin-2-thiones (3) with different aromatic aldehydes and chloroacetic acid in presence of acetic anhydride, anhydrous sodium acetate and glacial acetic acid. These compounds were characterized by their analytical and spectral data. The title compounds were found to be efficient antibacterial agents on evaluation. Top Keywords Imidazothiazole, Biological Activity, Antibacterial Activity. Top |