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Year : 2011, Volume : 35, Issue : 1
First page : ( 31) Last page : ( 35)
Print ISSN : 0250-4758. Online ISSN : 0973-970X. Published online : 2011 June 1.

Pathological studies on experimentally induced hydropericardium syndrome in immunosuppressed broiler chickens

Kumar S.1, Gupta R.P.1,*, Lather Deepika1

1Department of Veterinary Pathology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar-125004, Haryana

*Corresponding author: e-mail: rpgupta2007@yahoo.co.in

Received:  15  April,  2011; Accepted:  28  May,  2011.

Abstract

The effects of cyclosporine A (T-cell suppressor) was studied in chickens experimentally infected with hydropericardium syndrome (HPS) virus. The clinical signs of HPS were more severe and lasted longer due to administration of cyclosporine A (CsA) in HPS infected birds. The mortality due to HPS was more in CsA plus HPS group as compared with HPS group at different intervals. The characteristic gross and microscopic lesions in different organs observed due to HPS virus infection were of severe magnitude and longer lasting in CsA plus HPS group as compared to the HPS group at different intervals. HPS infected birds had significantly decreased delayed type hypersensitivity (DTH) response in comparison with the control birds against dinitrochlorobenzene antigen and this reduction in DTH response was significantly more in CsA plus HPS group as compared with the HPS group. It may be concluded that CsA enhanced the severity of HPS infection and thus suggesting the role of T-cells in limiting the pathology and pathogenesis of HPS.

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Keywords

Chickens, Cyclosporine A, Delayed hypersensitivity, Hydropericardium syndrome, Pathology.

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