Progressive Agriculture
Year : 2023, Volume : 23, Issue : 1
First page : ( 45) Last page : ( 52)
Print ISSN : 0972-6152. Online ISSN : 0976-4615.
Article DOI : 10.5958/0976-4615.2023.00006.6

Heterogeneous graphene oxide (GO) catalysed efficient and rapid synthesis of pyrazole derivatives and evaluation of their anti-cancer activity

Kumar Ajay^*

Associate Professor Chemistry Department, NAS College, Meerut, Uttar Pradesh, India

^*Corresponding Author Email- drajaykumar738@gmail.com

Online published on 20 May, 2023.

Abstract

An environment friendly method has been developed for the synthesis of drug like molecules economically, in one pot through a three-component reaction. The methodology has wide substrate scope under green reaction condition with low catalytic loading (0.05 wt.%). Taking into account the toxic effect of using metal-catalyst, Graphene Oxide catalysed efficient synthesis of pyrazole derivatives has been described herein for the synthesis of heterocyclic scaffold.Molecules synthesized were evaluated for their anti-cancer activity, showing strong inhibitory action against cell line A-549, thereby strengthening the knowledge of existing theories on cancer cells. The method involves reuse of recovered catalyst without loss in activity and yield, along with easy purification techniques.

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Keywords

Pyrazoles, Anti-cancer, Heterogeneous catalysis, Green chemistry, Michael addition.

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