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Research Journal of Pharmacology and Pharmacodynamics
Year : 2022, Volume : 14, Issue : 4
First page : ( 219) Last page : ( 224)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.52711/2321-5836.2022.00038

Comparative phyto and physico-chemical standardization of fresh and different market samples with the anti-inflammatory studies of fruit parts of Malva sylvestris L.

Mustafa Akhlaq1,*, Ali Mohammed2

1Research Officer (Chemistry), Drug Standardization Research Unit (Central Council for Research In Unani Medicine), Janakpuri, New Delhi

2Phytopharmaceuticals Research Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India

*Corresponding Author E-mail: amh786786@gmail.com

Online published on 9 March, 2023.

Abstract

Different extracts and the powder of fruits of Malva sylvestris L. (Malvaceae) are traditionally used in the treatment of sore throat, inflammatory chronic bronchitis, jaundice and urinary discharge diseases, and were tested for anti-inflammatory activity in albino rats. The aqueous and ethanol extracts showed significant anti-activity against carrageenan-induced paw oedema. The study includes a comparative Phyto and physicochemical study of fresh and different market samples of the drug, which was carried out under various parameters like successive extractability values, total ash, acid insoluble ash, water soluble ash, alcohol soluble matters, water-soluble matters, pH values of 1% and !0% aqueous solutions, moisture contents, total phenolics, tannins, resins and screening of phytochemical constituents in different extracts. Quantitative elemental analysis by Atomic Absorption Spectrophotometer and the study of characteristics of oil so obtained from petroleum ether extract e.g. saponification value, acid value, peroxide value, ester value, specific gravity, unsaponifiable matter etc. and thin layer chromatography in different extracts were also reported. Beside, the composition of fatty acids was found to be as Lauric (1.87%), Myristic (6.04%), Palmitic (37.53%), stearic (9.93%), Oleic (26.17%), Linoleic (14.36%) and (C20-C22) (4.03%).

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Keywords

Anti-inflammatory activity, Physico and Phyto-chemical, Malva sylvestris, Indomethacin, Standardization.

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