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Research Journal of Pharmacology and Pharmacodynamics
Year : 2022, Volume : 14, Issue : 4
First page : ( 253) Last page : ( 256)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.52711/2321-5836.2022.00043

An updated review on doxycycline

Jodh Rahul*, Tawar Mukund, Gomkale Kiran, Jari Sakshi, Toply Jafer, Faisal Nawed

Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati - 444602

*Corresponding Author E-mail: jodhrahul@gmail.com

Online published on 9 March, 2023.

Abstract

The structural isomer of the tetracycline family is doxycycline. It's a semi-synthetic medication with antibacterial properties against a wide range of germs and excellent intracellular penetration. Bacterial resistance can take many different forms, although the ribosomal or plasmid pathways are the most common. Propionibacterium acnes has gained antibiotic resistance in most cases due to an ARNr mutation. Doxycycline has antiinflammatory effects that manifest themselves through a variety of methods. Doxycycline is quickly absorbed and practically fully absorbed in the GI tract. Food does not affect absorption. With 90% of the molecule attached, it has a strong but fragile affinity for proteins. The majority of tissues and the extravascular compartment are swiftly absorbed. The most common method of excretion is through the bile canal. The bile channel is used for elimination. Tubular reabsorption in the kidney slows down. If you have acne, the daily dosage should be between 50 and 100 micrograms. Despite the scarcity of high-quality assays, there is widespread professional support for their use. It is also effective for rosacea at the same dosage. Doxycycline is being used as a backup antibiotic for chlamydial and mycoplasma urethritis. Additional diseases that can be treated as primary or secondary alternatives include treponematoses, brucellosis, pastoralizes, borreliosis, rickettsiosis, and cholera. Some non-infectious illnesses have been treated with doxycycline. The most common side effects are those that affect the digestive system. Esophageal poisoning has been treated with tablets and plenty of water.

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Keywords

Antibiotics, Doxycycline, Tetracycline, Anti-microbial, P acne, Yersinia pestis.

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