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Research Journal of Pharmacology and Pharmacodynamics
Year : 2022, Volume : 14, Issue : 4
First page : ( 268) Last page : ( 272)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.52711/2321-5836.2022.00046

A review on non-steroidal anti-inflammatory drugs induced kidney diseases

Pavani P.1,*, Naveena E.2, Subhashini P.2, Srikanth S.2, Naik K. Thirumala3, Babu M. Kishore4

1Pharm D, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh

2Pharm D, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh

3Associate Professor, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh

4Principal, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh

*Corresponding Author E-mail: pavanichowdary.para1196@gmail.com

Online published on 9 March, 2023.

Abstract

Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are used as over-the-counter drugs for Analgesic and Anti-inflammatory conditions. They inhibit prostaglandins synthesis by acting on Cyclooxygenase enzymes in the Arachidonic cascade which causes various abnormal effects like peptic ulcers, Gastrointestinal bleeding, sodium and water retention, hypertension, hemodynamic kidney injury, nephrotoxicity, stroke, and myocardial infarction when used for a longer duration, especially in older patients/comorbidities patients/pre-existing renal disease patients. This is because in older patients decrease in glomerular filtration rate and comorbidity conditions increase the risk of NSAIDs and cause Acute Kidney injury, Tubulointerstitial nephritis, and chronic kidney injury. NSAIDs do not cause much risk in patients who are young, without pre-existing kidney disease and without comorbidities. Physicians should educate patients with caution on the usage of NSAIDs for longer periods and should prescribe drugs in a dose-dependent manner.

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Keywords

Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, Acute Kidney Injury, Tubulointerstitial Nephritis, Chronic Kidney Disease.

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