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Asian Journal of Research in Pharmaceutical Science
Year : 2011, Volume : 1, Issue : 1
First page : ( 9) Last page : ( 16)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.

Biomarkers: An Emerging Tool for Diagnosis of a Disease and Drug Development

Sahu Pradeep1,*, Pinkalwar Neha1, Dubey Ravindra Dhar1, Paroha Shweta2, Chatterjee Shilpi1, Chatterjee Tanushree1

1Institute of Pharmacy, RITEE, Chhatauna, Mandir Hasaud, Raipur, Chhattisgarh, India

2Siddhi Vinayaka Institute of Technical Sciences, Mangla, Bilaspur, Chhattisgarh, India

*Corresponding Author E-mail: sahupradeep47@gmail.com

Online published on 5 June, 2014.

Abstract

Biomarkers provide a dynamic and powerful approach to understanding the spectrum of disease with applications in observational and analytic epidemiology, randomized clinical trials, screening and diagnosis and prognosis. Defined as alterations in the constituents of tissues or body fluids, these markers offer the means for homogeneous classification of a disease and risk factors, and the can extend our base information about the underlying pathogenesis of disease. A prerequisite for the clinical use of biomarker is elucidation of the specific indication, standardization of analytical methods, characterization of analytical features, incremental yield of different markers for given clinical indications. Biomarkers can also reflect the entire spectrum of disease from the earliest manifestations to the terminal stages. The major use of biomarkers in clinical investigation.

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Keywords

Diagnosis, Biomarker, Drug developments, Disease, Clinical Investigation.

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