(18.97.14.83)
[ij] [ij] [ij] 
Email id
 

Indian Journal of Animal Research
Year : 2019, Volume : 53, Issue : 4
First page : ( 505) Last page : ( 509)
Print ISSN : 0367-6722. Online ISSN : 0976-0555.
Article DOI : 10.18805/ijar.B-3528

Effect of feeding high fat diet on reproductive parameters in male mice

Samuel Rosa J.1,*, Joy Omana2, KrishnaMurthy P.3, Iyer Shruthi, Ramachandra S.G., Thamaraiselvi K.1

Central Animal Facility, Division of Biological Sciences, Indian Institute of Science, Bangalore-560 012, Karnataka, India

1Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli-620 024, Tamil Nadu, India

2FACS Facility, Division of Biological Sciences, Indian Institute of Science, Bangalore-560 012, Karnataka, India

3Department of Animal Science, Bharathidasan University, Tiruchirappalli-620 024, Tamil Nadu, India

*Corresponding author's e-mail: rosaj66@hotmail.com

Abstract

The present study attempts to chronicle the series of changes starting from the consumption of high fat diet till reproductive activity in male mice. A marginal increase in body weight was observed in male mice fed with high fat diet with 3-fold increase in total body fat and 1.4-fold increase in adipose tissue. A significant reduction in number and diameter of seminiferous tubules were observed in high fat diet fed mice compared to control mice. FACS analysis of testicular germ cells revealed very high percentage of apoptotic cells (84%) compared to control animals (2–3%) indicative of reduced spermatogenic activity. In addition, a significant decrease in litter size (11.6%-Control to 3.66%-HFD) indicates that reproductive efficiency in high fat diet fed mice reduced to a great extent. The present study revealed high fat diet alters the fertility in male mice significantly and the first in this process appears to be apoptosis of testicular cells due to increase in ROS.

Top

Keywords

Apoptosis, High fat diet, Infertility, Obesity, Reproductive failure, Spermatogenesis.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
834,948,764 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.