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International Journal of Medical Research & Health Sciences
Year : 2019, Volume : 8, Issue : 9
First page : ( 21) Last page : ( 24)
Online ISSN : 2319-5886.

Evaluation of fibrinolytic efficacy of Averrhoa Bilimbi linn. by using euglobulin lysis time method

Almarshad Feras M*

Department of Internal Medicine, College of Medicine, Shaqra University, Shaqra, Riyadh, Saudi Arabia

*Corresponding e-mail: feras-mmm@hotmail.com

Online published on 1 October, 2020.

Abstract

Background

An impaired fibrinolytic function had been reported in subjects suffering from venous thrombosis. The euglobulin clot lysis time is a test that reflects the overall fibrinolytic activity of plasma.

Objective

To evaluate the fibrinolytic efficacy of ethanolic extract of Averrhoa bilimbi Linn. leaves by using Euglobulin lysis time method.

Methods

Rats were divided into 3 groups. Each group was containing 6 rats. Group I: received vehicle (control) 0.9% saline solution; Group II: received 25 mg/kg ethanolic extract leaves of Averrhoa bilimbi Linn; Group III: received 50 mg/kg ethanolic extract leaves of Averrhoa bilimbi Linn. Blood (1.8 ml) was removed with a plastic syringe containing 0.2 ml 3.8% sodium citrate solution. The time interval between the addition of thrombin and the complete lysis of the clots was measured. The lysis time (min) was determined.

Conclusion

We observed ethanolic extract of Averrhoa bilimbi Linn. leaves may increase the activators of the fibrinolysis. Further investigation is warranted.

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Keywords

Euglobulin lysis time, Thrombin, Fibrinolysis, Blood clot, Averrhoa bilimbi Linn.

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