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BIOINFOLET - A Quarterly Journal of Life Sciences
Year : 2024, Volume : 21, Issue : 1
First page : ( 39) Last page : ( 40)
Print ISSN : 0973-1431. Online ISSN : 0976-4755.
Article DOI : 10.5958/0976-4755.2024.00013.0

Molecular docking on IL-17 cytokine suppression by the ligands of Wrightia tinctoria R. Br., an anti-psoriasis medicine

Chittibabu C. V., Nagavalli K, Gnanasekaran T, Pandi Santhana P, Guruprasad A.

Department of Plant Biology and Plant Biotechnology, Presidency College (Autonomous), (University of Madras), Chennai - 600 005, Tamil Nadu, India

Online published on 26 March, 2024.

Abstract

Interleukin-17 (IL-17) plays an important role against many autoimmune and inflammatory disorders, by triggering. p38 mitogen-activated protein kinase. IL-17 of Wrightia tinctoria R. Br. Is useful in folk medicines for the treatment of skin diseases with special reference to psoriasis. Wrightia tinctoria possesses five active ligands, viz., desmosterol, indigotin, indirubin, isatin and tryptanthrin, Those are considered as drugs to control psoriasis. Of them, used indigotin is regarded as a effective novel medicine for dermatological disorders.

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