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Research Journal of Pharmacology and Pharmacodynamics
Year : 2024, Volume : 16, Issue : 1
First page : ( 15) Last page : ( 18)
Print ISSN : 0975-4407. Online ISSN : 2321-5836.
Article DOI : 10.52711/2321-5836.2024.00003

Pharmacological evaluation of Lactuca canadensis. linn extract on anti-inflammatory activity in experimental animals

Dhokane Yashashri P.*, Akhtar Umair

Department of Pharmacology, Vidyabharati College of Pharmacy, C.K. Naidu Road, Camp, Amravati - 444602 (Maharashtra) India

*Corresponding Author E-mail: yashree61604@gmail.com

Online published on 4 May, 2024.

Abstract

Background

The body's defence mechanism against hazardous stimuli is inflammation. This procedure not only eliminates the harmful stimuli but also aids in starting the tissue's wound-healing process. Studying the effects of Lactuca canadensis linn. leaves extract in a croton oil-induced inflammatory model is the goal of the current investigation in an effort to discover a novel herbal remedy for the treatment of inflammation.

Methods

Alkaloids, Terpenes, flavonoids, and carbohydrates were found in the Lactuca canadensis Linn leaves extract, according to the phytochemical screening Diclofenac sodium injection (1ml/kg) is a common medication. Croton oil was injected into the left hind paw's subplantar surface in a quantity of 0.1ml. Using a vernier calliper, the volumes of the injected paws were measured before and 0, 1, 2, 3, and 5hours after the croton oil challenge.

Result

The herbal aqueous leaves extract of Lactuca canadensis Linn. showed promising efficacy by lowering the paw volume in comparison to the control group as a result of its anti-inflammatory action for Croton oil caused Rat paw edoema. At doses of 200 and 400 mg/kg, the aqueous extract significantly (P 0.05) reduced paw oedema by 33.11% and 44.4% on hour five.

Conclusion

The findings of this investigation show that the leaves' aqueous extract has significant (P 0.05) anti-inflammatory potential.

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Keywords

Inflammation, Aqueous extract, Croton oil, Paw edema, Lactuca canadensis Linn, Herbal medicine.

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