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Journal of Immunology and Immunopathology
Year : 1999, Volume : 1, Issue : 1&2
First page : ( 37) Last page : ( 40)
Print ISSN : 0972-0561.

Listeria ivanovii upregulate expression of OvCD4 and OvCD8 T-cell antigens in naturally infected ewes

Khatri M., Sharma R., Chand P.

Department of Veterinary Microbiology, College of Veterinary Sciences, CCS Haryana Agricultural University, Hisar, (Haryana) - 125004.


Four naturally infected ewes with Listeria ivanovii were investigated to examine the proportions of T lymphocyte subpopulation in peripheral blood. The levels of lymphocyte subpopulation were analysed in cytosmears of peripheral blood mononuclear cells by enzyme immuno-assay employing OvCD4, OvCD8 and OvCD5 specific monoclonals. Infected ewes had significantly increased proportions of both OvCD4+ and OvCD8+ T lymphocytes than uninfected ewes of the same age (P<0.005). However, the proportion of OvCD5+ T lymphocytes were not significantly different from that of uninfected ewes. The ratio of OvCD4+ and OvCD8+ T lymphocytes remained at low ebb during the infection.


Key words

Listeria ivanovii, OvCD4, OvCD8, T-cells, Ewes.


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