Asian Journal of Research in Chemistry
  • Year: 2009
  • Volume: 2
  • Issue: 4

Synthesis and Anti-Bacterial Study of 6, 8-Disubstituted -3-(4-(4-Substituted Phenyl) Thiazol-2-yl)-3,4-Dihydro-2H-Benzo [E][1,3] Oxazine

  • Author:
  • Kiran J Suthar, Harsha U Patel, Chhaganbhai N Patel, Vimal Patel
  • Total Page Count: 3
  • Page Number: 437 to 439

Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind Baug, Mehsana-384001, Gujarat, India

*Corresponding Author E-mail: kiran_pharma84@yahoo.co.in

Online published on 13 March, 2013.

Abstract

6, 8-Disubstituted -3-(4-(4-Substituted Phenyl)Thiazol-2-yl)-3,4-Dihydro-2H-Benzo[E][1,3]Oxazine have been prepared from 2-amino 4-substituted Phenyl thiazole react with substituted salicyladehyde results in 2,4-disubstituted -6-((4-(4-substituted phenyl)thiazol-2-ylimino)methyl)phenol. Then reacted with NaBH4, it give 2,4-disubstituted -6-((4-(4-substituted phenyl)thiazol-2-ylamino)methyl)phenol. Which is reacted with fomalin in chloroform yields 6, 8-Disubstituted -3-(4-(4-Substituted Phenyl)Thiazol-2-yl)-3,4-Dihydro-2H-Benzo[E][1,3]Oxazine. All the title compounds characterised on the basis of their MASS, 1H NMR spectroscopic data analysis.

Keywords

Synthesis, Thiazole, salicyladehyde, Anti-Bacterial activity