Mechanochemistry is the emerging branch of chemical science which obeys the principles of green chemistry. The power of mechanical friction is the source of energy for completion of reaction. Basically it was classified in the metallurgical sciences but due to its compatibility and ease of practice it will readily adopted in science of chemical synthesis. Organics as well as inorganic substances can be subjected to modification by virtue of it. It appears to be a science with a sound theoretical foundation which exhibits a wide range of potential application. The simplest and best example is of KBr plates; it will induced by milling and pressing of analyte with KBr to form a disk for IR spectroscopy, resulting in a change of the spectrum of the analyte. So it was worthwhile to adopt this technique in synthesis of pharmaceuticals.
Green Chemistry, Mechanochemistry, Mechanical Friction, synthesis
