Exploring the Pharmacokinetics and safety of Avocado Seed Extract: A Novel Antioxidant Scrub Formulation

Brown rice (Oryza nivara Linn.) and avocado seed (Persea americana Mill.) are Both are known for their high antioxidant content, which could potentially offer significant health benefits. This study aims to predict the pharmacokinetic and toxicity profile of avocado seed and evaluate a whipped scrub combining brown rice and avocado seed. Researchers will evaluate the efficacy and safety of this formula as an antioxidant agent. This study involves the ADMETlab 2.0 application in assessing the drug-likeness of compounds, namely SAscore and NPscrore. SAscore (synthetic accessibility score) shows the potential of a compound to be synthesized. Drug-Likeness evaluation resulted in compounds of ferulic acid, lutein, cholorogenic acid, rutin, phlorizin, vanillic acid, isoquercitrin and quersetin. have relatively low skin permeability having logKp>-2.5. Ferulic Acid, Lutein, and Quercetin potentially have high toxic potential in skin sensitization, Ferulic Acid, Vanilic Acid, and Quercetin also have the potential to irritate the eyes. In contrast to the prediction results of pkCSM, states that all eight compounds are safe when applied to the skin. Avocado seeds were formulated into a preparation of whipped brown rice scrub combined with avocado seed extract, with avocado seed concentrations of 2.5% (F1), 5% (F2) and 7.5% (F3). The physical quality results show that all formulas meet the requirements of good characteristics. The viscosity of the preparation increased every week. The results of the IC₅₀ value in F1 amounted to 1,654.02ppm, F2 924.20ppm and F3 726.03ppm. The whipped scrub formula is categorized as a rather low-potency antioxidant.