Dissolution Enhancement of Clarithromycin by Formation of Surfactant Containing Microparticles

The slow dissolution rate exhibited by poorly water-soluble drugs is a major challenge in the development process. Following oral administration, drugs with slow dissolution rates generally show erratic and incomplete absorption, which may lead to therapeutic failure. The aim of this study was to improve dissolution rate. Microparticles containing the model drug (clarithromycin) were produced by spray drying the drug in the presence of a surfactant. Poloxamer 407 was chosen as the surfactant to improve particle wetting and therefore the dissolution rate. The spray-dried particles were characterized and in vitro studies were carried out. The result obtained shows that dissolution rate of spray-dried clarithromycin and Poloxamer 407 particles were increased. Clarithromycin is water insoluble drug, after formulation of microparticles solubility is increased.