An Updated Overview: Floating (Gastroretensive) Drug Delivery System

Oral drug delivery system is most convenient and commonly used route of drug administration. More than 50% of drug available in market are meant for oral administration. The conventional drug therapy results in fluctuation of drug concentration, causing either toxic effect or no therapeutic effect. But now a day, recent technologies have been developed in research. Technological attempts have been made in the research and development of rate-controlled oral drug delivery systems to overcome physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bio-adhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices.