Granulation Technology: Current Status and Recent Advances

Granulation is performed to a powder or mixture of powder in order to improve flow, uniformity of contents and increasing the compressibility etc. In present review article we summarized the latest developments in granulation technologies behind most commonly used granulation process. Article deals basic information along with advantages and disadvantages of various granulation methods. Granulation step is the first important process which assures the pharmaceutical elegant solid dosage form. Need of large amount of granulating agent and subsequent drying leads to various deteriorating effects which diverted the formulators for newer techniques. The latest technologies includes steam granulation, melt/thermoplastic granulation, moisture activated dry granulation (MADG), moist granulation technique (MGT), thermal adhesion granulation process (TAGP) and foam granulation have their own advantages and these new techniques increases the interest of formulation developers in exploring a highly precise method to overcome the disadvantages of conventional granulation process such as dust generation or deteriorating effect of heat at drying step. Further validation of newer techniques for uniformity of batches is required which assures the quality of finished product.