Actin mediated up regulation of GLUT-4 in response to aqueous leaf extract of Aloe barbadensis miller

Insulin and several other drugs like metformin and rosiglitazone are known to cause increased synthesis and transport of GLUT-4 from intracellular storage compartments to the plasma membrane, which is mediated by actin and other cytoskeletal components. It is well documented that Aloe vera has anti-diabetic activity and the hypoglycemic effect is mediated by up regulation of glucose transporter protein GLUT-4 followed by increased uptake of glucose in the cell. Here, we have investigated in vitro for the effect of actin gene and GLUT-4 in mouse embryoblast cells treated with Aloe vera extract. We have observed an increased transcription of actin gene and GLUT-4 in the cells treated with the aqueous leaf extract of Aloe vera (Aloe barbadensis Miller)