A survey was conducted in 300 children from 7–18 years of age, of which 150 children identified anomalies of occlusion, including 118 with VAT, observed in 2015–2019 in the center "Dentistry" at the base of the Bukhara medical Institute and the regional children's dental clinic. Immunological studies were conducted in 118 children with NND with combinations of HPA and 32 children without pathology of HPA and without hPa. Among the parameters of immunity at the system level, serum immunoglobulins were considered: class a, M, G, and e immunoglobulins. In 22% of children, Parents noted a nasal tinge of speech, despite the ENT treatment at preschool age. From the anamnesis, it was found that in children with NND in 62% of cases, two or three diagnoses of ENT disease were established in the anamnesis. NND caused by chronic nasopharyngeal diseases persisted for a long period of time in 46% of patients. Thus, on the basis of the obtained research results, a new scientific idea was formulated and scientifically justified regarding the systemic immunity of children with HND and HFA, which allowed to enrich the scientific concept of humoral immune system dysfunction and identify new patterns of the studied combined pathology.
Occlusion, Immunoglobulins, ENT Disease, Pathology
