Infectious mononucleosis due to the virus epstein-Barr: Clinical and pathogenetic aspects

Epstein-Barr virus and infectious mononucleosis are synonymous for many physicians. Epstein-Barr virus causes approximately 90% of cases of infectious mononucleosis, while the rest of the cases are associated mainly with cytomegalovirus, human herpesvirus type 6, toxoplasmosis, HIV infection and adenovirus. Aim. Pathogenetic, clinical and epidemiological features of Epstein-Barr virus infectious mononucleosis have been analyzed as well as the problems of its diagnosis and treatment. Material and methods. The article presents an overview of Russian and foreign literature data on Epstein-Barr virus infectious mononucleosis. Results and discussion. In connection with significant increase in the incidence of infectious mononucleosis caused by Epstein-Barr virus in recent years, improvement of specific diagnostic methods and antiviral therapy will successfully solve the problem of arresting pathological process at the early stages of the disease. However, the problem of chronic forms of the disease requires in-depth study. Conclusion. The key to success in treatment of patients with infectious mononucleosis is timely diagnosis, correct individual approach to etiotropic and pathogenetic therapy, as well as timely hospitalization of patients with severe forms of infectious mononucleosis.