The influence of defiency of microelements in children with bronchial hyperreactivity

The study shows pathogenetic mechanisms of formation of bronchial hyper reactivity associated with microelementosis. The study group consisted of 58 children with a combination of atopic dermatitis and bronchial asthma. Methods: inhalation-provocation tests with histamine and metacholine, atomic absorption spectrometry, x-ray fluorescence method. The state of hyperreactivity of the bronchi was accompanied by a deficit of essential microelements (69.6%) with high sensitivity of the bronchi (PK20 metacholine, histamine-0.125–0.5 mg/ml), against the background of selenium and zinc deficiency (plasma content below 0.2 and 0.35 mg/l, respectively), reducing the speed parameters of the external respiratory function. Determination of the ME content in blood serum (Se, Zn)was performed by atomic absorption spectrophotometer. Mathematical calculations were performed using the statistical analysis package Microsoft Excel. When working with the database, the arithmetic mean values and standard errors of the arithmetic mean (M ± m) were determined. The sensitivity of the receptor apparatus of the bronchial tree was studied by means of an inhalation-provocation test with histamine and metacholine by the dose method [13]. Standard histamine solutions were prepared from histamine phosphate powder and buffer phosphate salt solution in concentrations 0, 125; 0, 25; 0, 5; 1; 2; 4; 8; 16 mg/ml. The control group consisted of 68 children with no history of atopic or chronic bronchopulmonary diseases and having the last acute respiratory illness more than 1 month before the study.