Study of the hepatoprotective action of rutan

In this work, the pharmacological action of Rutan on the biliary function of the liver in white rats is evaluated in experimental acute hepatitis. At the beginning of the work, toxic damage to the liver was simulated in white rats by subcutaneous administration with carbon tetrachloride. After that, the drug rutane was administered at a dose of 25 mg/kg for 5 days. The results of the studies showed that on the 6th day after the toxic damage, an increased level of ALT, a decreased level of the de Ritis coefficient and the level of total protein in the blood serum were observed. On histological sections of the liver of white rats, foci of fatty degeneration and necrosis of hepatocytes were observed causing a violation of the structural organization of the organ Under the influence of rutan, the survival rate of rats with toxic hepatitis increased and the state of blood biochemical parameters (ALT, AST, total protein) improved. The experiment revealed that the drug rutan is promising in the prevention and treatment of diseases of the hepatobiliary system.