Clinical-research based and morphological evidence of features of the course and treatment effectiveness of periodontal tissues and oral mucosa in animals under the impact of sodium hypochlorite

The aim is to substantiate the clinical course and pathogenesis of lesions of periodontal tissues, oral mucosa and liver in animals with sodium hypochlorite in experimental conditions and to evaluate the effectiveness of our developed methods of treatment. Material and methods. The study was performed on 60 white male mongrel rats weighing from 120 to 170 g. The animals were repeatedly exposed to sodium hypochlorite (SHC) at a dose of 1/20 LD50 (225 mg/kg intragastric), approximating the actual intake of this drug in real conditions. Results. Experimental studies indicate that during the 90-day priming in the blood of animals, in the studied tissues increases the amount of lactic, pyruvic acids, glucose (in the blood), there is a decrease in glycogen levels and reduced activity of enzymes dehydrogenase (GDG, SDG, MDG), which confirms the activation of glycolysis and inhibition of the potential of redox processes in the tissues of the body of animals. Summary. It was found that after the toxic effects of SHC on the general body and organs of animals PR is significantly reduced if in the conditions of priming animals specified harmful substance simultaneously carried out a set of recommended therapeutic and preventive measures.