Irritable bowel syndrome: A new look at the problem

Irritable bowel syndrome -a biopsychosocial disease that is a complex of functional disorders-that cannot be explained by the patient‘s organic changes in the intestine. The analysis of-modern data concerning the etiology and pathogenesis of the functional pathology of the digestive tract makes it possible to express an opinion on the concept of the formation of the disease. Obviously, it is not one, but several etiological factors that trigger also not one, but several pathophysiological mechanisms. And the complexity of the supervision of such patients lies in the fact that in each case, the combination of etiopathogenetic mechanisms is individual. Among them, of particular relevance today are: socio-economic status, genetic predisposition, the possibility of the formation of a child‘s disease by parents suffering from IBS, psychological aspects, visceral hypersensitivity, gastrointestinal motility, changes in the neuroendocrine system (brain - intestine axis), low-grade -inflammation, the concept of post-infectious IBS, microflora imbalance and, finally, nutrition factors.