1Associate Professor, Head of the Department of Faculty and Hospital Therapy, Uzbekistan Email id: dok_azim66@mail.ru
2Chilanzar College of Public Health named after Abu Ali ibn Sina, Uzbekistan Email id: teacher1201@mail.ru
Online published on 10 March, 2022.
The aim of this study was to study 129 patients with type 2 diabetes and 110 healthy people to determine whether the Leu28Pro polymorphic markers of the APOE gene are associated with the development of diabetic nephropathy (DN). Patients in the main group: 65 patients with a disease duration of up to 10 years, without diabetic nephropathy (33 patients) and with diabetic nephropathy (32 patients), 64 patients with diabetes lasting more than 10–20 years, with no diabetic nephropathy (31 patients) and diabetic nephropathy (33 patients). Genotyping was carried out by polymerase chain reaction. The study showed that the association of the Pro allele and the Leu/Pro genotype of the ENOS3 gene play a role in the development of diabetic nephropathy in patients with type 2 diabetes mellitus in the studied Uzbek nation.
Diabetic Nephropathy, Diabetes Mellitus, Gene, Polymorphism, Allele, Genotype
