Silver nanoparticles derivedfrombark extract of butea monosperma to detectanti-ulcer activity in swiss albino rats

The anti-ulcer activity of Butea monosperma silver nanoparticles (SNBM) was estimated in Swiss albino rats using ulcers caused by histamine, drugs, and ethanol. The effects of the SNBM at the doses of 300 and 550 mg/kg per os (p.o.) were compared with those of the reference pharmaceuticals, famotidine (35 mg/kg b.w.), and revealed substantial safeguards against ulcers generated by indomethacin and histamine. Additionally, the extract demonstrated excellent resistance against stomach ulcers brought on by ethanol. In addition, in ethanol-induced stomach ulceration, SNBM drastically lowered the spike in lipid peroxide level [(Thiobarbituric acid reactive substances (TBARS)] and restored the altered glutathione level. According to the study, SNBM demonstrates anti-ulcer efficacy by enhancing the gastric mucosa's antioxidant capacity and minimizing mucosal damage.