Application of the method of mathematical planning in order to select the optimal composition of the gel composition

This article presents the results of the scientific substantiation of the composition and development of the technology of the gel dosage form of dexpanthenol using the method of mathematical planning of the experiment. The type and concentration of the gelling agent, as well as the type of plasticizer, were chosen as factors. The amount of active substance released during the in vitro studies was the response. In most cases, multivariate methods are used, i.e. The effect of several factors at the same time is being studied. Both qualitative and quantitative indicators can serve as responses in these methods. Thus, as a result of the research carried out using the method of mathematical planning of the experiment, it was found that the type of gelling agent and plasticizer used has a significant impact on the release of the active substance from the gels, which is consistent with the well-known biopharmaceutical concept of the technology of dosage forms.