1Department Of Orthodontics and Dentofacial Orthopedics, Rajah Muthiah Dental College and Hospital, Annamalai University, Annamalai Nagar, Tamilnadu, India-608402
2Department Of Biochemistry, Rajah Muthiah Dental College and Hospital, Annamalai University, Annamalai Nagar, Tamilnadu, India-608402
3Department Of Oral Pathology, Rajah Muthiah Dental College and Hospital, Annamalai University, Annamalai Nagar, Tamilnadu, India-608402.
The purpose was to evaluate the influence of a NSAID, Diclofenac Sodium (DFS) on the tissue reaction related to orthodontic tooth movement (OTM).
27 adult male wistar rats were divided into 3 Groups of 9 each. Orthodontic closed coil spring was placed between rat incisor and molar to produce a 50 gm of force. The experimental Groups1 and 2 received orthodontic force and either DFS of 0.0025mg/0.05ml or 0.05ml of saline, Group 3 received only orthodontic force and served as a control group. At the end of day 5, 10 and 15 the animals were sacrificed and histological examination was performed.
Student's t test showed a statistically significant difference between the control Groups and experimental Groups. Group 1 showed a statistically significant reduction in osteoclastic cell count at day 5, 10 and15 when compared to Group 2 and Group 3.
The results indicate that the Diclofenac Sodium even at low concentration level diminishes the number of osteoclasts probably by inhibiting the secretion of prostaglandins there by reducing the OTM.
NSAID, Diclofenac Sodium, Orthodontic Tooth Movement (OTM)
