Sterile Abscess Secondary to Leuprolide Acetate

Background: Central precocious puberty is managed by long-acting gonadotropin releasing hormone (GnRH) agonists which are generally well tolerated in children. Sterile abscess formation is a rare complication of leuprolide acetate with no reported cases in the Indian literature. Objective: To report an adverse drug reaction of sterile abscess formation in a child following treatment with leuprolide acetate. Case summary: A young 1.5-year-old boy with central precocious puberty (CPP), was started on Leuprolide, a gonadotropin releasing hormone analog. He had recurrent abscess formation at the site of intramuscular injection. Evaluation of immune system for recurrent abscess was negative. The medication was subsequently changed to injection decapeptyl (triptorelin) which he tolerated well. Conclusion: This report describes adverse event of sterile abscess formation associated with the long-acting GnRH agonist leuprolide acetate which is used for the treatment of central precocious puberty in a child.