Challenges and Potential Therapies Associated with Onset and Progression of Alzheimer’s Disease

Alzheimer’s disease(AD) is a type of dementia, which is represented by intracellular neurofibrillary tangles and extracellular amyloid-beta (Aβ) protein deposits. There is no therapy reported for AD yet, although the available treatments can only improve the symptoms of the disease. Consequent upon this, an early and appropriate diagnosis is crucial to slow the evolution of the disease. For this many biochemical and molecular markers as Tau and Aβ levels in the blood and cerebrospinal fluid (CSF) are generally considered best for the diagnosis of AD. Several medical equipment are also used to verify the diagnosis including the medical history, mental status tests, and evaluations of the brain construction with neuroimaging techniques. Molecular Biology and Genetics is proved to be a precious tool to recognize the molecular origin of AD. There are many commercial drugs available which may reduce the severity of this dreadful disease but none of them is safe as they produce side effects so natural ingredients of herbs and other plants are focused primarily in this review to be therapeutic against AD.

Current review highlights the role of natural compounds on AD promotion and progression.