Therapeutic uses of prostaglandin (pgf₂α) in bovine reproduction

The use of prostaglandin (PGF₂α) is based on its luteolytic effect causing regression of corpus luteum. Moreover the use of PGF₂α causes relaxation of cervix and expulsion of uterine contents. The regression of CL allows development of dominant follicle on the ovary that results in estrus and ovulation in 72 to 96 hours after its administration. Under the influence of estrogen uterus becomes more resistant towards infection. Hence use of PGF₂α may provide microbial resistant uterine environment on one hand and can favour and enhance body defense mechanism/phagocytic activity on the other hand. PGF₂α is widely used get rid of cystic ovarian disease, persistent corpus luteum, endometritis, abnormal pregnancy, pyometra, retention of placenta and mummification. It has been now in vogue to administer PGF₂α or its analogue in early postpartum cows and buffaloes in order to hasten early resumption of cyclic ovarian activity and thereby to increase the reproductive efficiency.