Inhibitory effects of antibiotic from Nitrobacter spp. against Tinea capitis

This study was done to know sensitivity of antibiotic from Nitrobacter spp. against Tinea capitis disease. Many presently used antifungal agents have limitations (profound side effects, narrow antifungal spectrum, and poor penetration of certain tissues). Nitrobacter spp. was isolated from soil and its bacterial filtrate inhibited the growth of pathogenic dermatophytic fungi in following order: Microsporum fulvum > Microsporum gypseum > Trichophyton mentagrophytes. Optimal conditions (incubation period, temperature, pH and salt conc.) were also determined in In vitro conditions. Antifungal activity was directly associated with the growth of the isolate. The MICs of bacterial filtrate was evaluated and followed the order: Microsporum gypseum.> Microsporum fulvum > Trichophyton mentagrophytes. Therefore, the antibiotic from Nitrobacter gypseum may used to control disease causing Tinea capitis fungi.