*Professor, Doctor of Medical Sciences, Head of the Department of Infectious and Children's Infectious Diseases of the Tashkent Medical Academy, Ministry of Health of the Republic of Uzbekistan
**Candidate of Medical Sciences, Head of the Department of Chronic Viral Hepatitis, Republican Specialized Scientific and Practical Medical Center for Epidemiology, Microbiology, Infectious and Parasitic Diseases Ministry of Health of the Republic of Uzbekistan
Online Published on 03 January, 2022.
The results of the vast majority of studies of HDV infection indicate a high incidence of LC as an outcome of the disease with rapid development of liver decompensation. Against the background of rapid progress in the treatment of hepatitis C, the role of the insufficiently studied and difficult to treat HDV infection is currently increasing. The use of interferon preparations does not guarantee a cure in the majority of patients with delta infection, does not provide stable elimination of the virus, and gives many side effects. The presented methodological recommendations developed on the basis of the results of studies carried out in the clinical base of the RSSPMCEMIPD, showed that the administration of nucleoside analogs to patients with HDV infection significantly reduced the concentration of HBV DNA in the liver biopsy, which indicates a decrease in the risk of cytolysis in liver cells.
HDV Infection, HBV DNA, Replication, Liver Biopsy, PCR, Nucleoside Analogs
