Production of new antibiotic from marine fungi using biotechnology

Filamentous fungus are well-known for their capacity to produce natural antibiotics. Recent research has shown the potential of antimicrobials derived from marine fungus with broad chemo diversity. The conversion of such natural materials into lead compounds requires a long-term supply. At different stages of the process chain, including discovery, manufacturing, downstream processing, as well as lead development, marine biotechnology may make a major contribution to the creation of novel antibiotics. The number of biotechnological methods reported for large-scale production from marine fungus, on the other hand, is much less than the total number of newly found natural antibiotics. Marine fungal biotechnology methods or technologies are mainly derived from comparable terrestrial processes and seldom address the unique needs of marine fungus. Current advances in metabolic engineering and marine microbiology have yet to be translated into processes, but they provide a wealth of opportunities for improving industrial processes and establishing new process chains. The present status of biotechnological production of marine fungal antibiotics is summarized in this study, which highlights biotechnology's tremendous potential at all phases of the discovery-to-development pipeline. At the same time, the literature review indicates that further technological transfer and technique development are required for the production of marine fungal antibiotics to be sustainable and creative.