Experimental data on toxicity of zenkor herbicide

A comparison of the clinical symptoms of intoxication with detectable functional and morphological changes allows us to conclude that in the pathogenesis of Zencor poisoning, damage to the central nervous system is one of the first links. Manifestations of violations of its functional state are detected already in the first days of acute and in the first months of chronic poisoning. Judging by the dynamics of the development of pathological changes with the introduction of Zencor, along with the nervous system, the hematopoietic system is involved approximately simultaneously in the pathological process. Among the measures contributing to the increase of crop yields, the chemical method of controlling weeds, pests and pathogens of plants has gained great importance. In this case, we took into account the type of crops recommended for processing by Zenkor, which are widely used in food, not only for a healthy person, but also for children and sick people. Therefore, when calculating the allowable residual amount of the drug in food, we considered it appropriate to consider the average person's weight to be equal 50 kg Thus, on the basis of the conducted studies, it can be assumed that the main link in the pathogenesis of the toxic action of Zenkor is associated with the development of pathological processes in the central nervous system, to which the lesions of the hematopoietic and excretory, later digestive (liver, gastrointestinal tract) systems join. Based on a comparison of the chemical structure and toxicity of Zenkor with those of other triazines, we were able to identify that the replacement of isopropyl, butyl groups in the fourth and sixth positions with an amino group (Zenkor) leads to an increase in the toxicity of the chemical compound, which should be taken into account in the synthesis of new pesticides of this class.