Immune status in patients with duodenal ulcer and influence on her immunomodulatory therapy

The immunoreactivity was analyzed in 52 patients with duodenal ulcer (DU) and 36 healthy persons. The suppression of T-system and its subsets, a tension of humoral link of immunity was observed in patient. The use traditional method of treatmend was not made a result to disorder of second immunodificiens in patients with DU. The usage of Thymoptinum, the dose of which was 1, 0 mg-1, 2 mg (in one course) at second group patients (n=24) with DU cured immune disorder, increased cell immunity, and had immunocorrection and eradication features. In a retrospective analysis of the results of immunological examination presented in the table, it was found that the acute phase of DUD was accompanied by a decrease in the level of the general population of T-lymphocytes (CD3). Thus, DUD in the recurrence stage is characterized by a deep deficit of most of the parameters of the body's immune system with a high HP infection of GMM and DMM. Predictors of ineffective eradication are a significant decrease in the number of CD3, CD4 and IRI, as well as a decrease in the concentration of IgA. Apparently, a positive shift in the functioning of the T-cell (an increase in CD3, CD4 and a decrease in CD8) component of the immune system contributes to the eradication of HP. In addition, an increase in B-lymphocytes (CD19) and IgA levels was observed in this group compared to the data before treatment (p <0.001). The purpose of this study was to study the parameters of immunity in patients with DUD and conduct antihelicobacter and immunocorrecting therapy in them.