Cellular and hum oral immunity factors of animals vaccinated against the background of acute poisoning with dichloropropaphosomes

In this article, we presented the data of experimental studies on Karakul lambs with the dichloropropaphos pesticide tested in acute poisoning on cellular and humoral factors of animal immunity. This pesticide is a light oily liquid with a characteristic odor of dithiophosphates. Dichloropropaphos is an insecticide used to control pests of vegetable, citrus crops, vines, and cotton. The drug is considered medium toxic [2, 3, 6, 7]. However, the acute toxicity of the pesticide for young productive animals and the effect on immunobiological reactivity have not been studied. The aim of the work was to determine the degree of negative influence on the processes of formation of the immune response to various pathogens, and especially when vaccinating animals against infectious diseases. Acute intoxication of animals with this drug causes inhibition of the functional state of immunocompetent cells, which is manifested by a decrease in T-and B-lymphocytes and HCT-positive peripheral blood neutrophils; a decrease in total protein and its fractions, immunoglobulins of M and G classes and titers of specific antibodies in its serum. To a greater extent, the B-system of immunity is damaged. All this leads to the formation of active immunity of low tension and a significant decrease in the body's resistance to various infections.