Department of Pharmaceutical Analysis and Quality Assurance, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
*Corresponding Author E-mail: rohitreddy1610@gmail.com
Online Published on 23 January, 2024.
A simple, sensitive, accurate, precise and economical visible Spectrophotometric method was developed and validated for the estimation of Atorvastatin in Bulk form. The method is based on the reaction of Atorvastatin with MBTH Reagent [3-Methyl-2-Benzothiazolinone Hydrazone] in the presence of ferric chloride giving greenish blue colour chromogen which shows maximum absorbance at 566nm against reagent blank. The Chromogen obeyed Beer's law in the concentration range of 5-25 μg/ml for Atorvastatin. The results of the analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method.
Atorvastatin, MBTH Reagent [3-Methyl-2-Benzothiazolinone Hydrazone], Ferric chloride, Visible Spectrophotometric
