1Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Osmania University, Hyderabad, 500027, Telangana, India
2Department of Pharmacology, RBVRR Women’s College of Pharmacy, Osmania University, Hyderabad, 500027, Telangana, India
In Asia, Favipiravir, an anti- influenza medication, is widely available. Although having little proof of effectiveness, it has been widely utilised in the treatment of COVID-19. A simple UV spectroscopic method was developed for the determination of Favipiravir in pharmaceutical formulations. Favipiravir exhibited maximum absorption at 228 nm in 90% Ethanol and obeyed linearity in the concentration range of 0.5-25μg/ml. The proposed method was statistically validated. The % RSD < 2% indicates that method is precise. The % recovery results for accuracy in three levels i.e., 50%, 100% and 150% are 99.7, 99.7 and 99.8. Limits of detection and quantification were found to be 0.0435μg and 0.1318μg respectively. The ruggedness of method was studied with the help of different analyst. The robustness was performed in different 227 and 229nm. The developed UV method was validated and it was rapid, simple, sensitive and cost effective.
Favipiravir, Influenza, COVID 19, Validation, UV spectroscopy, Accuracy, Precision
