Q–Analysis Spectrophotometric method for the simultaneous determination of Nabumetone and Paracetamol in API and in tablet dosage form

A simple, sensitive and rapid Q –Analysis spectrophotometric method has been developed for simultaneous estimation of Nabumetone and Paracetamol from tablets. Here, absorbance is measured at two wavelengths. One being the λmax of Paracetamol (248.4 nm) and other being a wavelength of equal absorptivity of two components (238.6 nm) i.e. an isoabsorptive point. Linearity of response was observed in concentration range of 2 – 30 μg/ml for Nabumetone and 2 – 20 μg/ml for Paracetamol. The results of method were validated statically and by recovery studies. The % recovery was found to be 98.09% to 100.23% for Nabumetone whereas 99.88% to 101.81% for Paracetamol. The results of analysis in terms of % label claim was 98.72% ± 0.42 for Nabumetone and 101.62% ± 0.26 for Paracetamol for a formulation analyzed. The developed method was found to be accurate, precise, selective and rapid for simultaneous estimation of Nabumetone and Paracetamol in tablets.