College of Pharmacy, Shree Ganpati Institute of Technology, NH-24, Opp. Jindal Pipes Ltd, Ghaziabad, (U.P.) India
*Corresponding Author E-mail: jyoti.dahiya@sgit.ac.in
Online published on 19 June, 2014.
A simple, rapid and precise spectrophotometric method has been developed for determining the enhancement in the aqueous solubility Dextromethorphan. Method is based on the absorbance. Dextromethorphan maximum is found at 278nm with hydrotrope dextromethorphan in double distilled water as solvent. The linearity was obtained in the concentration range of 10–120μg/ml with coefficient of correlation 0.9993. The %RSD in case of intra-day and inter day was found to be 0.8182 and 0.9438 respectively. The value of LOD and LOQ was found to be 3.76 and 1.141 respectively. The method is found to be accurate, precise and useful in quality control of API Drug and also to enhance the aqueous solubility of Dextromethorphan.
Dextromethorphan, Hydrotropic Study, enhancement of solubility, Method Development and Validation
