Department of Pharmaceutical Analysis and Quality Assurance, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
*Corresponding Author E-mail: rohitreddy1610@gmail.com
Online published on 18 September, 2017.
A simple, sensitive, accurate, precise and economical visible Spectrophotometric method was developed and validated for the estimation of Cilazapril in Bulk form. The method is based on the reaction of Cilazapril with MBTH Reagent [3-Methyl-2-Benzothiazolinone Hydrazone] in the presence of Ferric chloride producing greenish yellow colour chromogen which shows maximum absorbance at 402nm against reagent blank. The Chromogen obeyed Beer's law in the concentration range of 10–50 μg/ml for Cilazapril. The results of the analysis have been validated statistically and recovery studies.
Cilazapril, MBTH Reagent, Ferric chloride, Visible Spectrophotometric
