Asian Journal of Pharmaceutical Analysis

  • Year: 2017
  • Volume: 7
  • Issue: 4

Synthesis of 2-(3-Substitutedamino-2, 4-Dithiobiuretoformamidino-4-isobutoxyphenyl)-4-Methyl-5-Carboxy-1, 3-Thiazoles

Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati, 444604

*Corresponding Author E-mail: anilsphd@gmail.com, skdtayade@mail.com

Online published on 2 June, 2018.

Abstract

A novel method has been developed for the synthesis of 2-(3-substitutedamino-2, 4-dithiobiuretoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1, 3-thiazoles by the reaction of 2-(3-substitutedthioamidoformamidino-4isobutoxyphenyl)-4-methyl-5-carboxy-1, 3-thiazoles with substituted isothiocyanate in 60% ethanol-acetone. The method provides rapid and easy access to compounds in good yields by using 60% ethanol-acetone medium.

Keywords

2-(3-Substitutedthioamidoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1, 3-thiazoles, ethanol, acetone