Asian Journal of Pharmaceutical Analysis

  • Year: 2018
  • Volume: 8
  • Issue: 2

Method Development and Validation of Cilazapril in Bulk Formulation by FC Reagent

Department of Pharmaceutical Analysis and Quality Assurance, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India

*Corresponding Author E-mail:

Online published on 7 July, 2018.

Abstract

A simple, sensitive, accurate, precise and economical visible Spectrophotometric method was developed and validated for the estimation of Cilazapril in Bulk form. The method is based on the reaction of Cilazapril with FC Reagent [Folin Ciocalteu] in the presence of Sodium Carbonate producing blue colour which shows maximum absorbance at 725nm against reagent blank. The Chromogen obeyed Beer's law in the concentration range of 10–50 μg/ml for Cilazapril. The results of the analysis have been validated statistically and recovery studies.

Keywords

Cilazapril, FC Reagent, Sodium Carbonate, Visible Spectrophotometric