Asian Journal of Pharmaceutical Analysis

  • Year: 2018
  • Volume: 8
  • Issue: 4

Determination of Dissociation Constant (PKA) of Enalapril maleate by Electromagnetic Instrument Based Method

1Mahatma Gandhi Vidyamandir's Samajshri Prashantdada Hiray College of Pharmacy, Loknete Vyanktrao Hiray Marg, Malegaon Camp, Malegaon-423105, Dist: Nasik, Maharashtra, India

2SSDJ SNJB College of Pharmacy, Chandwad Dist: Nasik, Maharashtra, India

*Corresponding Author E-mail: rakesh_2504@yahoo.co.in

Online published on 25 December, 2018.

Abstract

A simple, rapid and precise Electromagnetic Instrument Based Method (Conductometry and Potentiometry) has been developed for the determination of Dissociation constant. Dissociation constant is playing a great role in the drug absorption in vivo, especially in case of oral administration. So, in drug designing, pKa i.e. the negative logarithm of dissociation constant determination is very important. In this regards we report electromagnetic types of instrument-based procedures with principles elaborated to determine the Pka of Enalapril Maleate, an ACE inhibitor type of antihypertensive drug. The Dissociation Constant (PKa) of Enalapril Maleate was found to be 2.7 and 2.6 by the Potentiometric titration and Conductometry methods respectively.

Keywords

Potentiometer, Conductometer, ACE inhibitor, pKa (Dissociation constant)