1Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Venkatramapuram, Tirupati, Chittoor District, Andhra Pradesh-517561
2Department of Pharmaceutical Chemistry, Jyothishmathi College of Pharmacy, Turkapally (V), Shamirpet, (M) Medchal District, Telangana-500101
In the projected analysis work, a successful; attempt was made to develop simple, accurate, novel, ecofriendly and precise technique for the estimation of poorly water soluble drug Gliclazide in single drug containing dosage form. In the present investigation, a mixed hydrotropic blend of 2M urea and 6M trisodium citrate was used for quantitative determination. Gliclazide showed λ-max at 225 nm and beer's law was obeyed with in the concentration range of 4μg/ml-12μg/ml with mean recovery ranging from 95.33% to 96.35%. The developed technique was validated as per ICH guidelines.
Gliclazide, Urea, Trisodium citrate, Hydrotropy
