Asian Journal of Pharmaceutical Analysis

  • Year: 2019
  • Volume: 9
  • Issue: 2

Forced Degradation Study for Tolterodine by HPLC with PDA Detection

1School of Materials Science and Engineering, Changwon National University, Changwon, Gyeongnam, 641–773, Republic of Korea

2Department of Chemistry, Mahatma Gandhi University, Nalgonda, Telangana, India

3Department of Chemistry, Gitam University, Hyderabad Campus, Telangana, India

*Corresponding Author E-mail: tnraochemistry@gmail.com

Online published on 3 July, 2019.

Abstract

A simple and inexpensive method was developed with high performance liquid chromatography with PDA detection for determination of Tolterodine. The chromatographic separations were achieved on (250×4.6 mm), 5.0 μm make: X-terra C18 column employing Acetonitrile: 0.1% v/v phosphoric acid in Water (35: 65, v/v) as mobile phase with gradient programmed at flow rate 1.0 mL/min was chosen. The detector wavelength of 210 nm was employed.

Keywords

Forced degradation, HPLC, Method validation, Tolterodine