Asian Journal of Pharmaceutical Analysis
  • Year: 2019
  • Volume: 9
  • Issue: 3

Determination and Development of UV-Spectrophotometric method for the Amodiquine Hydrochloride by using quality by design (QBD) approach

1Research Scholar, R. C. Patel Institute of Pharmaceutical Education and Research, Shipur, Dhule (425405)

2Professor, Pharmaceutical Chemistry Department, R. C. Patel Institute of Pharmaceutical Education and Research, Shipur, Dhule (425405)

*Corresponding Author E-mail: sandipfirke@rediffmail.com

Online published on 31 December, 2019.

Abstract

To develop a simple, accurate, and inexpensive UV sepectrometric method for the determination of the Amodiquine hydrochloride by using quality by design (QbD) approach. The double beam spectrophotometer of Shimadzu UV-1800 by using a determination of UV spectrophotometer method. The amodiquine Hydrochloride is soluble with Distilled Water & methanol (9: 1) as solvent and wavelength of 341 nm was selected as of 0.998. The (LOD) and (LOQ) were amodiquine Hydrochloride recovery was found to be 99.6%.

Keywords

Quality by design, Amodiquine hydrochloride estimation, Spectrophotometric estimation